These are the vague memories I had of the men around me during my teenage years. Although I didn’t have true love at that time, the fascination with the same sex had quietly sprouted in my heart and formed the tone of my sexual orientation throughout my life. 01 I remember when I was in the third grade of elementary school, I was a little introverted and didn't like to talk to my family. At that time, something happened in my family and I had to live with my grandma. I had fair skin and bright eyes. Everyone said I looked like a girl, but I was also naughty and delicate. When I looked at the photos of myself at that time when I grew up, I thought I was really pretty. I have a cousin who always bullies me, but he would also lie for me, take me to play with friends, and do a lot of naughty things together. My cousin was handsome when he was a child, and he was considered to be more handsome among his friends. He was 5 years older than me, and he should have been in junior high school at that time. My cousin rarely stays at my grandma's house. He always comes to play with me for a while during the day and goes home at night. One night, probably because my aunt and uncle were out, my cousin and I shared a bed, and my grandmother slept in a bed next to us. When I was young, I didn't have any…
Thinking back now, I don’t think we ever really were on the same page. The first time I met him, I had this feeling that maybe something was inevitable. In the first semester of freshman year, we weren’t really familiar with each other. Our conversations were pretty shallow, and he was always the one to miss out on our late-night chats. I don’t even know when it started, but suddenly he got really into Dota, spending his days gaming with the guys in the next dorm. He didn’t care about anything else, not even his studies. He once mentioned that he didn’t enjoy studying medicine, and by the end of the first semester, it wasn’t a surprise when he failed a bunch of exams. His parents were called in for a talk. I happened to be the dorm leader back then, and we shared a room. My grades were decent, so when his parents invited me to dinner, they asked me to keep an eye on him, make sure he didn’t go online too much, and even gave me their contact number. This was the moment we started having more interactions. He’d always try to bargain with me to get on the internet, and sadly, despite my attempts, I couldn’t change him after all these years. The only thing I did was help him cheat to avoid failing. Meanwhile, he carried on with his carefree, somewhat extravagant lifestyle. For the next two years, we had this mundane and passive dynamic. By junior year, things subtly shifted. We moved to a…
This series is quite simple and doesn't offer much in terms of excitement. It's a typical college romance where the lead character is unsure whether his crush feels the same, even though they've already kissed. This kind of plot was very popular when BL series first gained traction, but now, as an audience, we have many more options. Even though the plot is thin, the series does offer plenty of light-hearted, fun moments between friends that keep you engaged for a while. However, with a total of 17 episodes, each ranging from 50 to 65 minutes, watching the entire show requires almost 16 hours. By the end, the investment doesn't feel entirely worthwhile, though it does manage to keep a smile on your face. The central story revolves around Easter and North, two college freshmen who are excited to begin their university lives and make new friends. Easter joins a club led by Hill, a popular medical student with three close friends, the most notable of whom is Johan, who comes from a wealthy family. From the start, it’s clear that Hill has feelings for Easter, and Easter likes him back, but Easter foolishly believes that Hill is interested in his sister or someone else. This happens even after Hill straightforwardly asks Easter if he wants to be his boyfriend. The show then delves into their backstories, showcasing their growing feelings for each other, although Easter sometimes behaves like a clueless child. Their romance is sweet and real, though not overly dramatic. It's a charming yet simple love story, focused…
A study presented at the 2024 HIV Drug Therapeutics Conference in Glasgow suggests that two broadly neutralizing antibodies (bnAbs), teropavimab and zinlirvimab, could be effective partners alongside lenacapavir in long-acting HIV treatments. The results emphasize the significance of screening for antibody sensitivity in HIV, while also proposing that people with partial resistance might still benefit from this combination if the dosing is sufficient. Lenacapavir (Sunlenca), administered as an injection every six months, is approved for people with multidrug-resistant HIV who have undergone extensive treatment. However, there is currently no other durable partner for lenacapavir to form a full six-month regimen, meaning it must be combined with daily oral antiretrovirals. Broadly neutralizing antibodies (bnAbs) show potential in fulfilling this role. While most individuals with HIV produce antibodies targeting highly variable parts of the virus (which can’t handle new mutations), a small group of individuals naturally produce bnAbs. These bnAbs target stable regions of the virus, making them more effective in neutralizing the virus across different strains. Research indicates that bnAbs are promising for HIV prevention, treatment (especially in children), and functional cures, though viral resistance can limit their use. Dr. Paul Cook and colleagues from East Carolina University tested a combination of lenacapavir with two bnAbs, teropavimab and zinlirvimab, both developed by Gilead Sciences. Lenacapavir is the first approved HIV capsid inhibitor. Teropavimab (GS-5423), derived from the bnAb 3BNC117, targets the CD4 binding site on the gp120 protein of HIV, which is a critical entry point for the virus into cells. Zinlirvimab (GS-2872), derived from the bnAb 10-1074, binds to the…
Briggs and researchers at the Max Planck Institute for Biochemistry have discovered the mechanism behind a crucial step in the HIV life cycle. In collaboration with teams from Heidelberg University and Yale University, they revealed that the mysterious "spacer peptide 2" (one of the HIV viral components) plays a key role in transforming immature HIV-1 particles into infectious particles. The research results have been published in the journal Nature. Key processes in HIV maturation HIV needs to undergo a maturation process to become infectious, which involves rearrangements in the structure of the matrix protein (red). In immature virus particles, the matrix protein forms a loose lattice structure (top right), while in mature HIV, the binding of spacer peptide 2 triggers the formation of a new, more stable lattice structure (blue, bottom right). © Illustration: Margot Riggi, MPI of Biochemistry. HIV-1 particle maturation HIV-1 particles are initially released from infected cells in an immature, non-infectious form. The main building block of the virus particle is about 2,000 copies of a long rod-shaped protein called Gag. To be able to infect host cells, HIV must go through a maturation process that involves the cleavage of Gag by HIV-1 protease (a viral enzyme), breaking it down into six smaller proteins, including the capsid protein and the matrix protein. This cleavage process results in a huge rearrangement of the virus's internal structure. Although scientists have been exploring structural changes in the viral capsid that envelops the genome for many years, comparatively little is known about the virosome, the protein shell beneath the lipid membrane…
There were two homosexuals in my high school class. There was a boy who was white, thin, tall, good at studying, with bangs that slightly covered his eyes. He had a calm and quiet personality and was favored by teachers and female classmates. At that time, we were still using forums, and everyone liked to post something on the campus forums. Most of the posts on the forums were just spam with little content. However, one day, a post appeared on the forum. I still remember the name of that post, which was called "Do you know Lin Xuyang?" Lin Xuyang is his name. The post begins with a few pictures of Lin Xuyang and another man. In the photos, they were shopping together, some were looking at each other, some were standing side by side. Lin Xuyang was smiling happily, I had never seen this expression on him at school. However, I don’t know why, but this picture of two good brothers makes me feel weird, as if... they are too intimate. Behind the picture were a few words from the poster. I don’t remember the details, but the general idea was that Lin Xuyang and that man had an improper relationship. That was my first exposure to the word “homosexual”. When I saw this word, I was shocked and felt a little uncomfortable. The post quickly went viral. The next day, on my way to school, I saw people secretly looking at him in the classroom, and occasionally people whispering to each other. At that time, most people…
Luca Guadagnino, a renowned director behind Call Me by Your Name and Challengers, now brings us into a new romantic world in Queer, adapted from the deeply personal work of William S. Burroughs. The result? A unique, striking film that stands out in its own right. Set in 1950s Mexico, the film follows William Lee (played by Daniel Craig), a wandering writer trapped in a life of alcohol and drug abuse. His existence is marked by indulgence, with little to anchor him. When not numbing his mind to cope with life's chaos, William spends his time with his mischievous gay friend Joe (Jason Schwartzman) or in the bars where fleeting encounters with young men occur—often with a price. William, a wandering dandy, drifts through life aimlessly, moving from one binge to the next, and from bar to bar. It is during one of these hazy nights that he encounters Eugene (Drew Starkey), a strikingly handsome young man who, with his Navy background, seems almost otherworldly. Eugene’s beauty, marked by a flawless face and perfect body, draws William in, sparking an immediate obsession. As they start spending time together, William's desire grows, and he wonders if he can seduce Eugene into his bed. But Eugene remains a mystery—ambiguous, detached, sending mixed signals while spending much of his time with Mary (Andra Ursuta), a woman he enjoys playing chess with. Eventually, one night, Eugene finds himself at William’s place, and they sleep together. In that moment, William feels a rare sense of aliveness, something he hasn’t experienced in ages. However, as the…
In early summer of 2009, I graduated from college. Fortunately, in this era, when many people are still worried about finding a job, I was lucky enough to pass the civil service exam. During the summer vacation, the last two months of vacation, I used it to play a huge joke on life because I entered the circle. By accident, after graduation, my class monitor and I went to see our counselor, mainly to collect our diplomas. Along the way, the squad leader talked to me about gay things. When I got home, I went online to the forum and added QQ. From then on, I started to hang out in this circle. After surfing the Internet for two months, I came to this city on the last day of August. And met him now. This way of getting to know each other is probably commonly used by many gays. I first saw him on QQ. I don’t know when he added me, but when I was bored and looking through my QQ friends from beginning to end, his photo attracted me. I went into his space and saw a lot of his photos. Indeed, I believe that anyone who likes men will definitely like him. He is mature, handsome and charming. It’s a pity that my thoughts were too simple at the time, otherwise so many things would not have happened later. I will talk about these things later. yes? Am I no exception? As soon as I saw him, I was attracted to him. The feeling of a…
There are many ways to come out, such as with classmates, friends, colleagues, and family. The difficulty and complexity of each are different due to the different relationships between them. Coming out to family is the most difficult and complicated. So I will focus on talking about some of the big and small things that happened when my boyfriend and I came out to our family. We are all family now. Let me first briefly introduce the two protagonists: I, 28, am from a small town in Sichuan, and I live and work in Guangzhou; he, 35, is from a rural area in Jiangxi (a real rural area, the nearest grocery store is several miles away), and he lives and works in Guangzhou. I met him in 2008. He was kind, considerate, tall and handsome... (cough, let's get down to business) In short, within two months, he forced me to live with him on the grounds that my residence was dirty and messy. One day not long after that, his mother came to Guangzhou to see him. Since we rented a one-bedroom apartment with only one bed, he scratched his head all day and couldn't figure out how to tell his mother. I was at work at the time, and he didn't call me in advance. It wasn't until I got home from get off work in the evening that he finally said to his mother: "I'm going to pick up a very important person (at that time he would pick me up at the bus stop every day, but…
Today I want to talk about my first love. It may not be considered a true love, but it was the first time I had emotional investment with a boy. For me, it has irreplaceable meaning in my life. It was the time before the exams in the second semester of my freshman year. The early summer sun was getting hotter and hotter. A senior in my senior year invited me to his rental house. I didn’t know anything and I was new to the circle, so I went there without thinking. Of course, the senior wanted to have sex. At that time, I thought that men only had sex. I never thought that two men could fall in love with each other, let alone get married and live together. At that time, I thought that two men having sex was driven by desire, which was sinful and dark, but it attracted me. I went to the senior classmate's place. He was not my type, a little bit effeminate. I thought he should be a 0, but he wanted to find me, a 0. I couldn't understand it. We chatted and watched TV. I had no intention of having sex with him, nor did I want to leave. At that time, I just wanted to stay with him and didn't want to go back to the dormitory. The senior classmate didn't want to chase me away, and he couldn't satisfy his desire, so he called his "brother" to come over. His brother is a 1, a pure 1, which means…
In early summer of 2009, I graduated from college. Fortunately, in this era, when many people were still worried about finding a job, I was lucky enough to pass the civil service exam. During the summer vacation, the last two months of vacation, I used it to play a huge joke on life because I entered the circle. By accident, after graduation, my class monitor and I went to see our counselor, mainly to collect our diplomas. Along the way, the squad leader talked to me about gay things. When I got home, I went online to the forum and added QQ. From then on, I started to hang out in this circle. After surfing the Internet for two months, I came to this city on the last day of August. And met him now. This way of getting to know each other is probably commonly used by many gays. I first saw him on QQ. I don’t know when he added me, but when I was bored and looking through my QQ friends from beginning to end, his photo attracted me. I went into his space and saw a lot of his photos. Indeed, I believe that anyone who likes men will definitely like him. He is mature, handsome and charming. It’s a pity that my thoughts were too simple at the time, otherwise so many things would not have happened later. I will talk about these things later. yes? Am I no exception? As soon as I saw him, I was attracted to him. The feeling of a…
It's been a year since I graduated, and I just want to use this text to commemorate our feelings, sometimes I miss him very much, but I'm afraid to disturb him, and I don't know what to do...... When he was in college, he and I weren't in the same class, but he used to come to our dorm to play because one of us was a fellow of his country. When I first entered the university, I was very reserved, and I was generally more Sven, and I let go after I got acquainted. I'm an introverted guy with a bit of shyness, and sometimes a bit headstrong. He is an athletic boy with a hearty personality and a dimple when he laughs, which is very sexy. He played basketball very well, joined the varsity team, played defense, and later won the championship of the varsity competition. I'm a basketball idiot, and I usually only like to play table tennis and badminton, which are not too strenuous sports. Later, I also learned some shooting moves in physical education class, and when I happened to hit a few heads during practice, they praised me for my basketball talent. I just laughed, and with my size, I still knew what I could do. But he was still very happy in his heart, so he said provocatively: Let's compete, whoever loses will have dinner. I'm one-on-one with him, and if I hit one before he shoots 10 balls, I win. I know he's provoking me, but I think he's too arrogant, although…
